FA Cup holders Manchester United will welcome former academy coach Warren Joyce back to the club as Wigan were handed an away tie at Old Trafford in the fourth round of the FA Cup.
It will be the first time Joyce returns to the club in a management role and it promises to be an intriguing tie.
Arsenal will face a potentially tricky trip to Southampton, while Chelsea will host London rivals Brentford.
Premier League giants Manchester United, Manchester City and Chelsea all cruised through the third round, while Arsenal also navigated their way past a plucky Preston side with a 2-1 victory.
City thumped West Ham 5-0, while United and Chelsea put four past Reading and Peterbrough in 4-0 and 4-1 wins respectively.
Tottenham Hotspur also kept their name in the hat after beating Aston Villa 2-0 at White Hart Lane and will face Wycombe Wanderers in the next round.